Catalytic Nucleophilic Glyoxylation of Aldehydes
نویسندگان
چکیده
منابع مشابه
Catalytic enantioselective nucleophilic addition of ynamides to aldehydes.
The first catalytic asymmetric addition of ynamides to aliphatic and aromatic aldehydes is described. This reaction provides unprecedented access to a diverse family of N-substituted propargylic alcohols that are obtained in high yield and ee in the presence of 10 mol% of zinc triflate and N-methylephedrine. The use of apolar solvent mixtures is essential to avoid product racemization and to op...
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ژورنال
عنوان ژورنال: Organic Letters
سال: 2010
ISSN: 1523-7060,1523-7052
DOI: 10.1021/ol100996w